α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid
4EGI-1
CAS: 315706-13-9
Molecular Formula: C18H12Cl2N4O4S
α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid - Names and Identifiers
α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid - Physico-chemical Properties
| Molecular Formula | C18H12Cl2N4O4S |
| Molar Mass | 451.28 |
| Density | 1.58±0.1 g/cm3(Predicted) |
| Boling Point | 668.9±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 35 mg/mL |
| Appearance | Brown solid. |
| pKa | 0.89±0.41(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | 4 gi-1 disrupts the eIF4F complex and inhibits Cap-mediated translation in vitro. 4 gi-1 has pro-apoptotic activity in Jurkat cells, and can effectively inhibit cell growth in A549 lung cancer cells, and its IC50 value is about 6 μm. In human lung cancer cells, 4gi-1 increases TRAIL-induced apoptosis by inducing DR5 and down-regulating c-FLIP, separate inhibition of cap-dependent protein translation. In addition, in chronic lymphocytic carcinoma, 4gi-1 restores sensitivity to ABT-737 through cap-dependent and non-dependent mechanisms. 4 gi-1 disrupts the eIF4F complex and inhibits Cap-mediated translation in vitro. 4 gi-1 has pro-apoptotic activity in Jurkat cells, and can effectively inhibit cell growth in A549 lung cancer cells, and its IC50 value is about 6 μm. In human lung cancer cells, 4gi-1 increases TRAIL-induced apoptosis by inducing DR5 and down-regulating c-FLIP, separate inhibition of cap-dependent protein translation. In addition, in chronic lymphocytic carcinoma, 4gi-1 restores sensitivity to ABT-737 through cap-dependent and non-dependent mechanisms. |
| In vivo study | 4EGI-1 (75 mg/kg, i.p.) inhibits breast cancer stem cells (CSC) tumor growth and tumorangiogenesis in vivo. 4EGI-1 (75 mg/kg, i.p.) shows inhibitory effect on the tumor volume and weight in mice bearing U87 cells. |
α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.216 ml | 11.08 ml | 22.159 ml |
| 5 mM | 0.443 ml | 2.216 ml | 4.432 ml |
| 10 mM | 0.222 ml | 1.108 ml | 2.216 ml |
| 5 mM | 0.044 ml | 0.222 ml | 0.443 ml |
Last Update：2024-01-02 23:10:35
![α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid](http://res.chembk.com/assets/images/structure/315706-13-9.gif)
Supplier List
Product Name: 4EGI-1 Visit Supplier Webpage Request for quotation
CAS: 315706-13-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 315706-13-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: 4EGI-1 Visit Supplier Webpage Request for quotation
CAS: 315706-13-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 315706-13-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History